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This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Velikova T Immunological aspects of inflammatory bowel disease pathogenesis. Home Contact Us Follow us on :. About us About Us Providing cutting-edge scholarly communications to worldwide, enabling them to utilize available resources effectively Read More.
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Immunological aspects of cancer chemotherapy.
Minimally invasive surgery in urology: Edited by Inderbir Gill. Immunological aspects of minimally invasive oncologic surgery. Current Opinion in Urology18 2 , March Add Item s to:. An Existing Folder.
Immunological aspects of intestinal mucus and mucins.
A New Folder. The item s has been successfully added to " ". Thanks for registering! Be sure to verify your new user account in the next 24 hours, by checking your email and clicking the "verify" link. The main complications after bone marrow transplantation BMT are graft versus host disease GvHD , post-transplant viral infections and disease relapse. The underlying causes of these problems are the degree of HLA matching between donor and patient and the rate of immune reconstitution.
Keywords: Bone marrow transplantations, HLA matching, alloreativity, immune reconstrution.
Myasthenia Gravis: Clinical and Immunological Aspects
Studies have shown that recipients of transplants from unrelated donors that are matched for these HLA antigens have a lower risk of acute GvHD than recipients of marrow from mismatched VUD. However, the incidence of GvHD is still much higher than that observed for HLA-identical sibling transplants and there is no improvement in overall survival of HLA-A, B, DR matched unrelated marrow recipients when compared with mismatched related marrow recipients. Thus, the benefits of HLA matching on survival after transplantation with unrelated donor marrow have been controversial.
It is clear that additional factors must influence the success of unrelated BMT. HLA typing of unrelated individuals for class I antigens is often still performed by serology and class II typing is performed by a combination of serology and cellular and molecular assays. DNA sequencing analysis has identified over one thousand HLA alleles and many more remain to be discovered.
It is now evident that the complexity of the HLA system can not be resolved by serology because each serologic specificity actually comprises many different molecular subtypes. For example, there are currently more than one hundred recognised HLA-A alleles but only a fraction can be identified by serology.
DNA-based methods are therefore required to achieve high resolution HLA typing for better matching of unrelated donors and patients. We have developed a novel DNA-based typing technique that offers a high level of resolution similar to direct sequencing techniques but without the problems of interpretation associated with heterozygous samples.
Chimeric duplexes are formed between locus-specific, fluorescent labelled, reference strands FLR and the HLA alleles from the sample to be typed.